The effects of inactivation of the baroreceptor reflexes arising from the aortic arch [by vagotomy] and/or the carotid sinuses [by carotid occlusion] on arterial blood pressure [ABP] in dogs were compared. The effects of inactivation on the drop in pressure consequent to a standard blood loss were also compared. The carotid basoreceptor reflex was found to be atrue buffer system. Its inactivation resulted in a higher increase in ABP and a more drop in blood pressure after bleeding than inactivation of the aortic one. The aortic reflex seemed to be important only as an antihypertensive mechanism, mainly activated when blood pressure raised above the normal level