This work was carried out on two groups: Group I included 30 patients with 44 tattoos of different sizes and site seeking detattooing with which was carried by the sequential excision technique. Excision was done first at 5/10th of a mm thickness, then if still needed another 2/10th mm skin excision was done. Remaining pigments were left to be rejectedon the dressing. The results were very satisfactory postoperatively. Group II included the whole skin obtained from ten cadavers carrying tattoos. Specimens obtained from groups I and II were processed, stained with [H and E] and examined microscopically with a graduated lens to detect the concentration of pigments at different levels. In both groups, the pigments were found to be concentrated in the upper 7 mm and rarely deeper than 8 mm around the vessels in the pericytes macrophages. The latter findings recommend that two sequential excisions of not more than 7/10 mm skin are sufficient and that a third excision entails the risk going too deep. Furthermore, the technique is a reliable controllable and adjustable gratifying detattooing maneuver