Thirty cases of incisional hernias with large fascial defects were repaired with mersilene mesh as “in-lay graft” to bridge the defect. Two cases showed postoperative wound infection, which has been controlled without any further complications. Follow up for one year showed only one case of recurrence [3.3%] . The results of this work showed that mersilene mesh can be used safely and effectively in the repair of large incisional hernias