Studies of the use of immunotherapy as an adjuvant modality in the multimodal treatment [RICH regime] of breast cancer indicated that it had a promising and strong effect. Immunotherapy alone is difficult to act, as it acts on a small number of tumor cell, thus, it should be used with other cytoreductive modalities. Patients receiving immunotherapy [lethally irradiated autografts from cancer cells and levamisole] showed improvement in humoral and cell-mediated immunity, recurrence-free interval and survival time after mastectomy. Immunotherapy, by the manner described in this work, is simple and well tolerated and leads us to advice its use on a wider scale