Chronic liver diseases, mainly due to schistosomiasis, is a common clinical feature in Egypt. On the other hand, Toxoplasma latent infection is another common feature. This paper aimed to study the role of Toxoplasma latent infection in patients with chronic liver diseases mainly due to schistosomiasis. The latent Toxoplasma infection was measured by the positivity of IgG to ELISA and the negativity of IgM to DS-ELISA. The cellular immunity was assessed by the dinitrochlorobenzene [DNCB] skin test. The clinical and the laboratory studies showed that latent Toxoplasma infection had no marked effect on the progression of the chronic liver diseases