Chromosome-centric human proteome project [C-HPP] is a recent initiative to rationalize and analyze gene-protein and protein-protein interactions in normal and disease conditions. This initiative is aimed to generate the proteomic atlas explaining the molecular architecture of the human body and was initiated in response to the hurdles identified during analyzing the human genome project [HGP] . A need for the experimental observation of translated proteins was felt to analyze precisely what is going on in the cell.25 countries around the world are participating in the C-HPP. This symposium report will introduce the Y-chromosome HPP which is undergoing in Iran by eminent molecular biologists of Royan Institute, Tehran and its collaborates