In this study, the effects of the broad spectrum anthelmintic drug, levamisole, on the cardiovascular system of rats were investigated. Male albino rats weighing 160 +/- 15 g each were used.
were divided into four groups. Experiments were conducted under urethane anesthesia. The first group was intraperitoneally [i. p. ] injected with saline, while the other groups were [i. p. ] injected with 10, 20 and 40 mg/kg b. wt. of levamisole, respectively. The electrocardiogram [ECG] and the arterial blood pressure were recorded simultaneously. Treatment with either of the three doses of levamisole induced a significant increase in both heart rate and conduction velocity. Some cardiac disorders, such as sinus arrhythmias and nodal rhythm, were also noticed. Levamisole also produced a significant hypertension. It can be suggested that levamisole has a stimulating effect on the release of adrenaline from the adrenal gl and as a result of its ganglionic stimulating activity
M. Fayez ,
A study of the effects of levamisole on some cardiovascular parameters of rats,
Alex. J. Vet. Sci. 1994;
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