Background: A positive autologous serum skin test [ASST] reflects the presence of anti-Fc Epsilon RI and/or anti-IgE autoantibodies and used to show autoimmunity in cases with respiratory allergies.
Impaired CD4+CD25 [high] FoxP3+ T regulatory cell activity can cause autoimmune diseases and allergy Objective: To investigate the association between respiratory allergies and CD4+CD25 [high] FoxP3+ T regulatory T cell count and re-evaluate the significance of ASST reactivity in respiratory allergy patients and healthy controls
Methodology: 16 patients with persistent asthma, 14 seasonal allergic rhinitis patients and 30 control subjects were included. ASST and measurement of FoxP3+ regulatory T cell count was performed in all subjects Results: ASST was positive in 18/30 [60%] respiratory allergic patients and none of control subjects. FoxP3+Treg cell count was lower in respiratory allergic patients than control subjects with negative correlation with disease severity
Conclusion: Respiratory allergic patients have lower level of FoxP3+ regulatory T cell than normal individuals. A positive ASST response found in respiratory diseases patients suggests that it may occur as a result of some inflammatory events during the diseases process and could be related to disease activity
Ahmed . A. Shaheen ,Ahmed . A. Shaheen ,Manal M. Al Amen ,Maha Atfy ,Hoda Fathy ,Shereen A. Baioumy ,
A study on t regulatory cells in patients with respiratory allergies in zagazig university allergy and immunology unit,
Egypt. J. Med. Microbiol. 2016;
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