and review pertinent tomography literature contributing to this diagnostic challenge Case Report: A twenty six year-old male presented with bilateral blurring of vision for 2 weeks, for which he underwent full ophthalmologic examination, laboratory evaluation, B-scan ultrasonography, fluorescein angiography and spectral domain optical coherence tomography [OCT] . OCT disclosed multifocal intra-retinal lobulated cystic fluid collections with septae of variable thickness, disruption of the photoreceptor layer with choroidal thickening and hyper-reflectance in outer retinal layers Conclusions: APMPPE and acute VKH can present with substantial overlap in symptoms, signs and ophthalmic imaging characteristics. OCT offers valuable information about both shared and different features. A holistic approach is necessary to reach a proper diagnosis and plan treatment and follow up