To determine the frequency of anxiety and depression in patients undergoing chemotherapy for solid tumors using Hospital Anxiety Depression Scale [HADS] . Cross sectional descriptive study. Out-patient department of Armed Forces Institute of Mental Health, Rawalpindi from June 2011 to December 2011. Consecutive non probability sampling technique was used to select patients of age [25-70 years] , male or female, who had received atleast 03 cycles of chemotherapy for solid tumors. Those with history of prior psychiatric illness, current use of psychotropic medication or psychoactive substance use, and any major bereavement in past one year were excluded from the study. After taking informed consent, relevant socio- demographic data was collected and HADS was administered. HADS-A cut off score of 7 was taken as significant anxiety while a HADS-D cut off score of 7 was taken as significant depression. The total number of participants was 209. The mean age of patients was 42.9 years, with 55.5% males and 44.5% females. Overall 33/209 [15.8%] patients had anxiety while 56/209 [26.8%] were found to have depression. there was a higher frequency of anxiety and depression in younger patients [less than age 40 years] , females, patients who were single or divorced, and patients receiving chemotherapy for pancreatic carcinoma. Patients undergoing chemotherapy suffer from considerable levels of anxiety and depression, thus highlighting the need for specialized interventions