Hypothesis: A breakdown in the balance between cell survival and programmed cell death apoptosis has been implicated in the pathogenesis of autoimmune diseases as rheumatoid arthritis [RA] .
was elucidated the metalloproteinases [MMP] inhibitors have the potential to block the release of apoptotic signals from the cells, and active MMP-3 may be responsible for the shedding of these signals from the cell surface in the joints. The aim of this study was to investigate the relation between Apo-1/fas and stromelysin-1 [MMP-5] in the synovial fluid of rheumatoid arthritis patients Methodology: Synovial fluid concentration of Apc-1/fas and MMP3 aid MMP-9 were measured in 25 RA patients and 15 knee OA patients for comparison. in RA routine clinical examination and laboratory variables were assessed and correlated with two variables
Results: Concentrations of Apo-1/fas in synovial fluid in RA patient were significantly higher as compared to knee OA patients. Also the synovial fluid concentration of MMP-3 and 9 were significantly higher in RA patients as compared to knee OA patients. There was a high significant correlations between Apo-1/fas and MMP-3 [1-0.649] . There were significant correlations between Apo-1/fas and C-reactive protein [CRP] , rheumatoid factor [RA] titer, Ritchie articular index [MI] and knee joint score [KJS] Conclusion: There was significant correlation between the concentration of Apo-lifas and MMP-3 in synovial fluid in RA patients. Apo-1/fas was significantly correlated with marker of disease activity as CRP, RA titer, RAI and KJS. So be can concluded that fas mediated apoptosis could be involved in RA pathogenesis and MMPJ may be responsible for shedding of these signals in the joints of RA
Mahmoud Abdel Hamid El Sakka ,Mahmoud Abdel Hamid El Sakka ,Mohamed Hossam ,
Apo-i/ fas and matrix metalloprotinase3 [stromelysin-1]in synovial fluid of patients with rheumatoid arthrltis,
Zagazig Univ. Med. J. 2003;
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