Assessment of left ventricular function and volumes provides valuable information in patients with heart disease. It is also considered a prognostic marker in coronary artery disease. Two- dimensional transthoracic echocardiography is the most widely used method for Left Ventricular function assessment, but this modality is operator dependent and can be impaired by a poor acoustic window. To validate a single tertiary center experience in Multi Detector Computed Tomography for the evaluation of cardiac function in patients undergoing coronary CT angiography. A cross sectional study, conducted at Ibn Albitar center from September 2012 till May 2013. Patients included are those who already underwent 64-slice CT coronary angiography to evaluate known or suspected coronary artery disease, CT coronary angiography is performed using a 64- slice Multi Detector CT-scanner. Transthoracic Echocardiography was done by a single operator served as the reference standard. Eighty patients [66.3% male] were included in the study, the mean age was 53.19 +/- 10.6 years. The mean Left ventricular End Diastolic Volume by Cardiac CT and Echocardiography were 125.31 +/- 41.92, 126.75 +/- 41.894 ml respectively, with excellent correlation [r =0.912; P< 0.001] . Average Left ventricular End Systolic Volume [LVESV] by Cardiac CT and Echocardiography were 58.08 +/- 34.18, 53.74 +/- 33.15 mL respectively. With Excellent correlation coefficient [r = 0.971; P0.001] , with trends towards CT showing slightly higher values than that of Echocardiography. Average Left ventricular Ejection Fraction was 55.40 +/- 14.57% as determined by Cardiac CT, compared to 59.26 +/- 9.8% by Echocardiography, with good correlation between the two methods [r = 0.734; P=0.01] , although LVEF was slightly underestimated by Cardiac CT [3.86 +/- 9.9%; P0.001] . The current study showed that [our experience in the] assessment of cardiac function by CT is comparable to the commonly used 2D Echocardiography method. And can be used in patients already performing coronary CT angiography, [potentially for those in whom the images from TTE are inadequate.