Background: Hepatitis C virus [HCV] is associated with many dermatoses including psoriasis through stimulating inflammatory cells to infiltrate skin lesions Objectives: To assess serum osteopontin
[OPN] in psoriatic patients associated with HCV infection and its relation to severity and progression of psoriasis
Methodology: OPN was assayed by ELISA for 60 patients with psoriasis and 30 healthy individuals as control group Results: OPN levels [pg/ml] were 49.8+/-30.2; 110.9+/-50.2 and 284.0+/-45.3 in mild, moderate and severe psoriasis; respectively. OPN levels [pg/ml] were increased in 21 [35%] psoriatic patients with positive HCV antibodies [182.1+/-47.4] as compared to negative patients [49.87+/-13.5] . OPN correlated positively [r= 0.81; p< 0.0001] with psoriasis lesions and severity of psoriasis calculated by psoriasis area and severity index [PASI] score. Area under the ROC of OPN to discriminate psoriasis patients from healthy individuals; mild severity from moderate severity; mild severity from severe; moderate severity from severe were 0.93; 0.81; 0.88 and 0.86; respectively. HCV prevalence were 10.8%, 42.9% and 72.8% in mild, moderate and severe; respectively
Conclusion: There is a relation between serum OPN and HCV infection in psoriatic patients and level of OPN correlate with severity of psoriasis and also reflects progression of psoriasis in HCV infected patients.
Tarek Moustafa Emran ,Tarek Moustafa Emran ,Zakaria Mahran ,Mohamed M. Omran ,Mahmoud Farag Salem ,Ahmed Salama Al Adl ,Mahmoud Sad Berengy ,Ahmed W. Amer ,
Assessment of serum osteopontin level in psoriatic patients associated with hepatitis c virus infection,
Egypt. J. Med. Microbiol. 2017;
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