Background: hypertension [HTN] and chronic renal failure [CRF] are known risk factors for atherosclerosis. Oxidative stress has been implicated as an important etiologic factor in this complication.
Antioxidants can alleviate the process of thermogenesis through multifactorial reactions that finally inhibit lipid peroxidation Objectives: this work aimed to determine concentrations of the main antioxidant vitamins [serum alpha tocopherol, serum Beta-carotene and plasma ascorbic acid] in essential HTN and to assess the possible effect of hypertension due to end-stage renal disease [ESRD] on these antioxidant vitamins
Subjects and Methods: serum alpha-tocopherol, serum B-carotene and plasma ascorbic acid concentrations were determined by spectrophotometric methods in thoroughly diagnosed 20 patients with essential HTN and 20 patients with renal related hypertension [HTN+CRF] . Similar investigations were done for 15 clinically healthy control volunteers Results: serum concentrations of alpha-tocopherol were subnormal in both essential HTN and renal related hypertension [HTN+CRF] but the decrease was only significant in the latter group. Subsequently, the difference between the essential HTN renal related hypertension groups was significant. With regard to Beta-carotene, its serum concentration was significantly lower than normal in both essential HTN and HTN CAF but the difference between both patient groups was insignificant. With regard to plasma ascorbic acid, its concentration was significantly lower in both essential HTN and HTN + CRF groups than normal mean value but the mean value of plasma ascorbic acid in HTN+ CRF was significantly lower than that in essential HTN alone
Conclusion: HTN is significantly related to the main antioxidant vitamins [a-tocopherol, Beta-carotene and ascorbic acid] . CRF has an additive effect to HTN on both water soluble antioxidant vitamin [ascorbic acid] and lipid soluble forms [alpha tocopherol and Beta-carotene]
Mohammed M. El Arman ,Mohammed M. El Arman ,Ghada Mohammed Hassan El Kannishy ,Wael Mohammed Raghib Rifaie ,
Assessment of some antioxidant vitamins in essential hypertension and renal-related hypertension,
Mansoura Med. J. 2004;
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