Background: chronic inflammation, immune hyperactivity and/or immune suppression are elements of autoimmune disorders that predispose patients to lymphoma Aim: Screening for autoantibody e. g.
antinuclear antibody [ANA], antimitochondrial antibody [AMA] and it's correlation with the detection of serum interleukin-10 [IL-10] in a newly diagnosed non hodgkin's lymphoma [NHL]
Methods: A thirty five newly diagnosed NHL patients and 20 healthy control were studied immunologically for detection of autoantibodies [ANA, AMA] by using enzyme immunoassay and immunofluorescent and the detection of serum 1L-10 by enzyme immunoassay Results: The autoantibodies were recorded in 4 cases [11.4%] of NHL patients while serum 1 L-10 detected in 48.5% and only one case of AMA had detectable level of 1 L-10
Conclusion: The high frequency of positive autoimmune antibodies among patients with NHL at diagnosis, may indicates an association between the aetiologies of these disorders
Nahla G. Al Khayali ,Nahla G. Al Khayali ,Khalida M. Mousawy ,Abdul Wahab ALShaikly ,Leen K. Al Chalabi ,Jassim Al Khafagi ,
Auto-immune syndromes may be associated with and precede the development of non hodgkin’s lymphoma,
Iraqi Postgrad. Med. J. 2003;
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