Autoantibodies that target a soluble liver antigen/liver pancreas [SLA/LP] autoantibodies exhibit a high specificity for autoimmune hepatitis [AIM] and they characterize a third subgroup of AIM.
These autoantibodies directed against a 50 KD cytosolic protein identified as UGA suppressor serine tRNA-protein complex. The aim of the study is to know the prevalence and clinical relevance of anti-SLA/LP autoantibodies in AIH. The study was performed on 73 Iraqi patients with autoimmune hepatitis [AIM], attending the teaching hospital for gastroenterology and liver disease in the period between November 2003 and July 2004. The Anti- soluble liver antigen/liver pancreas autoantibodies [SLA/LP] was studied by Euroline method. Anti-SLA/LP was detected in 8 patients [11%] with AIH, with negative finding for antinuclear and liver/kidney microsomal antibodies, marker of two types of AIH, but never in the sera of control groups. The presence of anti-SLA/LP autoantibodies identified additional patients with AIH previously thought to suffer from cryptogenic hepatitis. Since, it was exclusively detected in AIH, this makesg it a diagnostic test for direct clinical relevance
Eman Sh. Al Obeidy ,Khalida M. Mousawy ,Maan G. Hasso ,Makki H. Fayadh ,Nawal M. Al Khalid ,
Autoimmune hepatitis: – another specific immune marker,
J. Fac. Med. -Baghdad. 2006;
61-63 Views : 0