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  4. Balloon valvuloplasty in dysplastic pulmonary valve stenosis: immediate and intermediate outcomes

Balloon valvuloplasty in dysplastic pulmonary valve stenosis: immediate and intermediate outcomes

Authors

Sehar Tayyaba
TheChildren's Hospital and Institute of Child Health ; , Department of Paediatric Cardiology ;

J. Coll. Physicians Surg. Pak. 2015; 25 (1): 16-21
JCPSP-Journal of the College of Physicians and Surgeons Pakistan
Journal Country: Pakistan
P-ISSN: 1022-386X
E-ISSN: 1681-7168
Type of Publication: Journal Article
Category: Humans, Male, Female,
Type of Research: Clinical
Keywords: Pulmonary Valve Stenosis / Therapy
Broad Subjects: Noncommunicable Diseases, Balloon Valvuloplasty ,Treatment Outcome ,Child
Citation: Tayyaba Sehar , Balloon valvuloplasty in dysplastic pulmonary valve stenosis: immediate and intermediate outcomes, J. Coll. Physicians Surg. Pak. 2015; 25 (1): 16-21

Abstract English

To determine the immediate and intermediate outcome in dysplastic and doming pulmonary valve stenosis in children and to determine various factors associated with unsuccessful outcome. An interventional study. The Children’s Hospital, Lahore, Pakistan, from June 2006 to December 2012. All patients presenting with severe pulmonary valve stenosis were enrolled in the study. Balloon valvuloplasty was performed on all patients. Successful outcome [residual gradient < 36 mmHg] was compared with matched doming pulmonary valve stenosis control group valvuloplasty. Difference in various quantitative variables was calculated using independent t-test and Mann Whitney U test. Categorical variables were compared using Chi square and Kruskal-Wallis test. Multivariate analysis was performed to determine various factors associated with outcome. Kaplan- Meier survival table was used to determine freedom from re-intervention proportions. One hundred and fifty two patients [Dysplastic group A, n=73; Doming group B, n=79] with median age of 24 months [range 3 - 192 months] and M: F; 2: 1 were included in the study. Mean gradient decreased from 96 +/- 33 mmHg to 29 +/- 20 mmHg. Group A had significantly higher number of patients with unsuccessful outcome [9.6%, p=0.02] . Preprocedure gradient > 75 mmHg was the most significant factor associated with unsuccessful outcome [p < 0.001] . Median follow-up duration was 3 years [range 1 - 6 years] . Freedom from re-intervention proportion at 1, 3 and 6 years was 91.3%, 86.7% and 78.9% respectively in group A compared to 100%, 96.5% and 96.5% respectively in group B. Immediate postprocedure gradient > 60 mmHg was the only significant factor associated with re-intervention in group A [p=0.001] . The results from balloon valvuloplasty in dysplastic pulmonary valve were suboptimal when compared to doming valves. However, it provides a high freedom from re-intervention rate in intermediate follow-up. Intervention at moderate severity can result in better outcome

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