Da-us-Sadaf [Psoriasis] is a common chronic, recurrent, immune mediated disease of the skin characterized by dryness, scaling and plaques. It is considered to be an autoimmune disease, caused by Sauda-e-Mohtaraq [burnt melancholic humor] and Merah-e-Sauda [burnt bile mixed with melancholic humor] . Psoriatic patients face many social and psychological problems because of its visibility, persistency and difficulty of being treat. Present paper deals with a report of a case study evaluating the efficacy of Psoralia corylifolia Linn. seeds as oral administration and Marham-e- Gulabi [non-pharmacopoeial Unani formulation] as topical agent in psoriasis, both clinically as well as histopathologically. It is concluded that the test drugs found to be safe, non toxic and highly effective for psoriasis