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  4. Comparison of intraocular pressure lowering effect of Latanoprost and Timolol combination versus Latanoprost alone in Primary Open Angle Glaucoma

Comparison of intraocular pressure lowering effect of Latanoprost and Timolol combination versus Latanoprost alone in Primary Open Angle Glaucoma

Authors

Dar Asad Jamal
Pak. Armed Forces Med. J. 2015; 65 (1): 94-98
PAFMJ-Pakistan Armed Forces Medical Journal
Journal Country: Pakistan
P-ISSN: 0030-9648
E-ISSN: 2411-8842
Type of Publication: Randomized Controlled Trial
Category: Humans, Male, Female,
Type of Research: Clinical
Keywords: Intraocular Pressure / Drug Effects
Broad Subjects: Health Systems, Prostaglandins F, Synthetic ,Timolol ,Glaucoma, Open-Angle
Citation: Asad Jamal Dar , Comparison of intraocular pressure lowering effect of Latanoprost and Timolol combination versus Latanoprost alone in Primary Open Angle Glaucoma, Pak. Armed Forces Med. J. 2015; 65 (1): 94-98

Abstract English

To compare the intraocular pressure [IOP] lowering effect of topical drug combination [Latanoprost and Timolol] with Latanoprost alone in patients of Primary Open Angle Glaucoma [POAG] . Randomized controlled Trials [RCT] . Armed Forces Institute of Ophthalmology [AFIO] Rawalpindi from December 2009 to May 2011. A total of 240 eyes of 120 patients [68 males and 52 females] were included in the study. The patients were randomized into two groups of 60 each using random numbers table. Group A [60 patients, 12Q eyes] were put on topical drug combination of Latanoprost and Timolol eye drops and Group B [60 patients, 120 eyes] were treated with topical Latanoprost eye drops alone. IOP assessments were done at baseline, 2 weeks, 4 weeks and 8 weeks intervals after initiation of treatment. Both the groups were age matched with mean age in Group A was 56.39 +/- 8.50 years and in Group B was 55.61 +/- 8.95 years [p=0.09] . Both groups showed significant IOP decrease from the baseline at each follow up interval. However after 8 weeks of start of treatment, pressure lowering effect in group A [14.73 +/- 2.50 mmHg] was significantly more as compared to Group B [9.10 +/- 2.51 mmHg] [p<0.001] . Combination therapy of Latanoprost and Timolol is more effective as compared to monoyherapy with Latanoprost in lowering IOP of patients with POAG

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