of Prosthodontics, Dr Ishrat ul Ebad Khan Institute of Oral Health Sciences, Dow University of Health Sciences Karachi and from 15th October 2012 to 25th March 2014 Results: The mean value for male and female subjects was 33.24 +/- 3.4 mm and 34.90 +/- 3.8 mm correspondingly. The mean width of maxillary central incisors for male and female subjects was recorded 15.84 +/- 1.4 mm and 15.92 +/- 1.3 mm. The value [P = 0.000] for both estimations were significant. The Pearson correlation coefficient were positive [r = 0.202] and highly significant [P = 0.008] between innercanthal dimension and the maxillary central incisors. The results indicated that innercanthal ratio ratio of 1: 0.462 may be used to calculate the combined width of maxillary central incisor teeth Conclusion: Mean of maxillary central incisor width and inner canthal distance were higher in females significantly. The results proposed that innercanthal distance is a good prognostic factor for determining the maxillary central incisors mesiodistal width