COVID-19 | Discover the latest peer-reviewed research articles from the Eastern Mediterranean Region
COVID-19 | Discover the latest peer-reviewed research articles from the Eastern Mediterranean Region
COVID-19 | Discover the latest publications published by WHO Regional Office for the Eastern Mediterranean
COVID-19 | Discover the latest publications published by WHO Regional Office for the Eastern Mediterranean

Virtual Health Sciences Library

  • Home
  • Search
  • Knowledge Base
  • Get a journal indexed in the Index Medicus
  • MyVHSL
  1. Home
  2. IMEMR
  3. Search Result
  4. [Correlation of helicobacter pylori vac A s, m region genotypes with different gastrodoudenal diseases in east Azerbaijan patients]

[Correlation of helicobacter pylori vac A s, m region genotypes with different gastrodoudenal diseases in east Azerbaijan patients]

Authors

Safaralizadeh Reza
Basiri, Zeynab
Hosseinpour Feizi, Mohammad Ali
Jabarpour Boniadi, Mortaza
Motaghi, Batol
Nemati, Masoumeh
University of Tabriz ; , Faculty of Natural Sciences ; , Department of Animal Biology ;

J. Kerman Univ. Med. Sci. 2015; 22 (1): 21-31
Journal of Kerman University of Medical Sciences
Journal Country: Islamic Republic of Iran
P-ISSN: 1023-9510
E-ISSN: 2008-2843
Type of Publication: Journal Article
Category: Humans,
Country of Research: Islamic Republic of Iran
Type of Research: Clinical
Keywords: Helicobacter pylori
Broad Subjects: Health Systems, Digestive System Diseases ,Duodenal Diseases ,Adenocarcinoma ,Bacterial Proteins ,Peptic Ulcer
Citation: Reza Safaralizadeh ,Zeynab Basiri ,Mohammad Ali Hosseinpour Feizi ,Mortaza Jabarpour Boniadi ,Batol Motaghi ,Masoumeh Nemati , [Correlation of helicobacter pylori vac A s, m region genotypes with different gastrodoudenal diseases in east Azerbaijan patients], J. Kerman Univ. Med. Sci. 2015; 22 (1): 21-31

Abstract English

Gastric adenocarcinoma has been considered as an infectious disease since 1994, when the Helicobacter pylori [H. pylori] infection categorized as a definite class I human carcinogen. H. pylori uses extensive numbers of virulence factors to overcome host defence mechanisms. One independent H. pylori factor that plays an important role in determining H. pylori pathogenesis is vacuolating cytotoxin A [vacA] . The purpose of this study was to investigate the frequency of vacA Genotypes, and also its association with disease outcome in infected patients. Antral gastric biopsy materials were collected from 88 patients with different gastroduodenal diseases. Genotyping of the VacA alleles were determined by PCR methods. Of 64 H. pylori positive patients, 38 were classified as gastritis, 11 as peptic ulcer, and 15 as gastric adenocarcinoma. Four Vac A genotypes were observed, including 20 [22.7%] for s1/m2 [with frequency of relatively equal in all groups] , 12 [13.6%] for s1m1 [with the highest frequency in gastric adenocarcinoma and peptic ulcer] , 7 [7.95%] for s2m2 [with the highest frequency in gastritis] and 3 [3.4%] for s2m1 [with the highest frequency in peptic ulcer] . In this study, no significant relationship was observed between the different genotypes of the vacA and the clinical outcome. Gastric adenocarcinoma also showed significant association with age and gender

Full Text Persian
4 Downloads

Subscribe to VHSL Newsletters

© 2020 WHO – EMRO