To assess the safety and feasibility of laparoscopic cholecystectomy as a day-case procedure. All consecutive patients who were admitted to the day-surgery unit for laparoscopic cholecystectomy at the Department of Surgery, King Saud Medical City, Riyadh, Saudi Arabia from July 2009 to June 2013 were considered for this retrospective study. The medical records were reviewed for age, gender, presenting symptoms, laboratory findings, imaging studies, American Society of Anesthesiology [ASA] grade, anesthesia, conversion to open cholecystectomy, complications, the operating surgeons, pain management, nausea, and vomiting, overnight stay, readmission, morbidity, mortality, and outpatient follow up were collected and analyzed. A total of 487 patients underwent laparoscopic cholecystectomy as a day case [ASA I=316, ASA II=171] . Surgery was performed by high surgical trainees [HSTs] [n=417] and consultants [n=70] with conversion to open cholecystectomy in 4 patients. Twenty-two [5%] patients were admitted for overnight stay for different reasons, while 465 [95%] patients were discharged before 8 pm. Two patients [0.4 %] were re-admitted to the hospital due to abdominal pain. Five patients developed umbilical port site infection [1%] . A total of 443 patients were satisfied [97%] , while 14 [3%] were unsatisfied. There was no mortality or intra-abdominal septic collection. Day-case laparoscopic cholecystectomy is safe and feasible with optimal patient selection, education, and planned postoperative antiemetic and analgesia management