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  4. Effect of drying phase on the agglomerates prepared by spherical crystallization

Effect of drying phase on the agglomerates prepared by spherical crystallization

Authors

Maghsoodi Maryam
Yari, Zahra
Tabriz University of Medical Sciences ; , School of Pharmacy ; Drug applied Research Center,

Iran. J. Pharm. Res. 2015; 14 (1): 51-57
IJPR-Iranian Journal of Pharmaceutical Research
Journal Country: Islamic Republic of Iran
P-ISSN: 1735-0328
E-ISSN: 1726-6890
Type of Publication: Journal Article
Type of Research: Non Clinical
Keywords: Carbamazepine
Broad Subjects: Health Systems, Crystallization ,Temperature ,Porosity ,Tablets
Citation: Maryam Maghsoodi ,Zahra Yari , Effect of drying phase on the agglomerates prepared by spherical crystallization, Iran. J. Pharm. Res. 2015; 14 (1): 51-57

Abstract English

In this paper, differences in porosity, compressive strength and tablet- forming ability of carbamazepine crystals agglomerated under similar condition, but subjected to different drying temperatures are reported. The agglomerates were prepared by spherical crystallization method and thereafter dried without agitation at different temperature. An increased drying temperature did not affect the shape and structure texture of dried particles and did not cause them to fracture. Drying of particles at higher temperature suppressed the particle contraction as a consequence of fast evaporation and hence produced particles of larger mean diameter, higher porosity and thus lower compressive strength than those dried at lower temperature. Through a relationship with particle porosity, the drying rate also affected the ability of particles to form tablets

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