The effect of glycemic control on body weight and blood pressure in 61 NIDDM patients with secondary failure was evaluated after 6 months of control. Patients were divided into three groups.
I [22 patients] received insulin, group II [21 patients] received a combination of insulin and glibenclamide, and group III [18 patients] treated with increasing the dose of their sulfonylurea agent. Mean body weight increased significantly in groups I and II. The percent increase in body weight was significantly higher in group II compared with group III. Mean systolic and diastolic pressures increased significantly in group I only. No significant differences in the percent changes in systolic or diastolic pressures between the three groups were found. Out of 61 patients, 29.5% showed either no change or a decrease in body weight, 44.3% and 62.3% showed either no change or a decrease in systolic and diastolic pressures, respectively. The study showed that glycemic control with insulin results in significant increases in body weight in the majority of patients. The effect on blood pressure was, however, variable with an increase in some patients and no change or even a decrease in others
A. Al Amin ,A. N. Abdel All ,A. Sadek ,
Effect of glycemic control on body weight and blood pressure in non insulin dependent diabetic patients with secondary sulfonylurea failure,
Bull. Alex. Fac. Med. 1994;
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