Evaluation of heat shock protein70 expression in liver biopsies of chronic hepatitis C Egyptian patients
Ahmed Asmaa Mahmoud
Gamal, Yasser
Hassan, Howayda Ismail
Omar, Abdel Hady Mohammed
Gamal, Yasser
Hassan, Howayda Ismail
Omar, Abdel Hady Mohammed
AssiutUniversity ; , Faculty of Medicine ; , Department of Pathology ;
Assiut Medical Journal Journal Country: Egypt
P-ISSN: 1110-0494 Type of Publication: Journal Article Category: Humans, Female, Male, Middle Aged, Country of Research: Egypt WHO Eastern Mediterranean Region Type of Research: Clinical
Keywords: Hepatitis C, Chronic
Board Subjects: Communicable Diseases, Heat-Shock Proteins ,Biopsy ,Liver
Citation: Asmaa Mahmoud Ahmed ,Yasser Gamal ,Howayda Ismail Hassan ,Abdel Hady Mohammed Omar , Evaluation of heat shock protein70 expression in liver biopsies of chronic hepatitis C Egyptian patients, Assiut Med. J. 2015; 39 (3): 1-8
Background/Aim: Heat shock protein 70 [HSP70] is a member of heat shock protein family It has strong cytoprotective properties that prevent cell death triggered by stressful stimuli The aim of this work was to study the immunohistochemical expression of HSP70 in chronic HCV biopsies among Egyptian patients Methods: Immunohistochemical stain using HSP70 was performed on 30 chronic hepatitis C needle biopsies, with different degrees of disease severity
Results: Positive HSP70 immunoreactivity was detected in 12/30 [40%] of the chronic hepatitis specimens with weak to moderate intensity. No statistically significant difference was detected between the mean of HSP70 expression and the following parameters; age, gender, necroinflammatory grade and stage of fibrosis [p=0.109, p=0.874, p=0.342 and p=0.182] respectively
