The aim of the study was to evaluate the presence of pre-clinical myocardial damage in insulin and non-insulin-dependent diabetic patients and controls by assessment with Doppler echocardiography.
Thirty insulin-dependent diabetic [IDDM] patients, 30 non-insulin-dependent diabetic [NIDDM] patients and 20 healthy individuals [C] as controls. They were matched for age, gender and without overt cardiovascular disease. Systolic function parameters were presented with increase in left atrial diameter and left ventricular thickness in the NIDDM group. Diastolic function was clearly ihpaired in both groups of diabetic patients versus than in healthy controls, in particular in the NIDDM compared with the IDDM patients. There was a significant direct correlation between peak late filling rate [A and age of the patients and a significant negative correlation between ] A and glycosylated hemoglobin [HbAlc] in both groups of patients. Also, there were significant inverse correlations between decelerat-ion slope [D-slope] and age, duration of diabetes in IDDM diabetic patients. In conclusion, Doppler echocardiography showed an early impairment of left ventricular diastolic filling as well as an early preclinical alteration of myocardial systolic function in diabetic patients especially in the NIDDM group
Mohammad Karim Azmy ,Mohammad Karim Azmy ,Moustafa Mohammad El-Naggar ,AbdEl Hamid Idress AbdEl Hamid ,Hatem AbdEl Latif Kholief ,Mohammad Hesham Hasan Ezzat ,
Evaluation of the impairment of left ventricular filling in insulin-dependent and non-insulin-dependent diabetic patients,
Al-Azhar Med. J. 2002;
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