Suez Canal University ; , Faculty of Medicine ; , Pathology Department ;
Suez Canal University Medical JournalJournal Country: Egypt ISSN: 1110-6999 Type of Publication: Journal Article Keywords: Female, Humans, Breast Neoplasms ,Immunology ,Immunohistochemistry ,Thrombospondin 1 ,Tumor Markers, Biological ,Predictive Value of Tests ,Prognosis
Fourty seven specimens of patients with breast carcinoma, received in the Pathology Laboratory of the Suez Canal University Teaching Hospital in the period between January 2001 to December 2002.
In each case two slides were stained, one to be routinely stained with H and E for histological evaluation. The other slide to be immunohistochemically [IHC] stained for Thrombospondin-1 [TSP-1]. Correlate these expression with the conventional prognostic factors. The staining intensity of most of the IDC cases was moderate. TSP-1 staining was confined in the cytoplasm in 79% of the cases while nuclear and cytoplasmic staining was seen in 21%. There was statistical significant relation between TSP-1 staining intensity status and tumor size. While no relationship could be found between TSP-1 staining pattern or cytoplasmic versus nuclear and cytoplasmic to various tumor sizes. Similarly, we failed to find a relation TSP-1 staining intensity status and the histological grade in cases of IDC NOS, and ILC. The role of TSP-1 in tumor progression is both complex and controversial. The rule of thrombospondin-1 as an anti-angiogenic factor is very interesting in inhibiting tumor cell adhesion, proliferation, motility, and invasion
Makram Hammam ,Wagdy Talaat ,Howayda Abdel All ,Magdy Korashy ,
Expression of Thrombospondin-1 in breast carcinoma: an immmunohistological study,
Suez Canal Univ. Med. J. 2006;
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