Flavonoids from salvia chloroleuca with alpha-amylsae and alpha-glucosidase inhibitory effect
Asghari Behvar
Imam Khomeini International University ; Shahid Beheshti University, Faculty of Engineering and Technology ; Medicinal Plants and Drugs Research Institute, Department of Plant Production and Breeding ; Department of Phytochemistry
IJPR-Iranian Journal of Pharmaceutical Research Journal Country: Islamic Republic of Iran
P-ISSN: 1735-0328 E-ISSN: 1726-6890 Type of Publication: Journal Article Type of Research: Experimental Studies
Keywords: Salvia
Broad Subjects: Health Systems, Flavonoids ,alpha-Amylases ,Drug Effects ,alpha-Glucosidases ,Drug Effects ,Enzyme Inhibitors
Citation: Behvar Asghari , Flavonoids from salvia chloroleuca with alpha-amylsae and alpha-glucosidase inhibitory effect, Iran. J. Pharm. Res. 2015; 14 (2): 609-615
It is believed that the inhibition of carbohydrate hydrolyzing enzymes including alpha-amylase and alpha-glucosidase is one of the therapeutic approaches to decrease the postprandial glucose level after a meal, especially in the people with type 2 diabetes. Medicinal plants and their extracts are one of the main sources to find new inhibitors to the enzymes. In our study four flavonoids, namely luteolin 7-O-glucoside [1] , luteolin 7-O-glucuronide [2] , diosmetin 7-O-glucuronide [3] and salvigenin [4] were isolated from aerial parts of Salvia chloroleuca. The inhibitory activity of these compounds against alpha-amylase and alpha-glucosidase were evaluated. Compounds 1, 2 and 3 showed potent alpha-glucosidase inhibitory effect with IC [50] values of 18.3, 14.7, and 17.1 microM, respectively. Also these compounds exhibited moderate alpha-amylase activity with IC [50] values 81.7, 61.5, and 76.3 microM, respectively
