Shiraz University of Medical Sciences ; , Shiraz Transplant Research Center ; , Nemazee Hospital ;
Middle East Journal of Digestive DiseasesJournal Country: Islamic Republic of Iran ISSN: 2008-5230 ISSN E: 2008-5249 Type of Publication: Journal Article Category: Humans, Adolescent, Child, Child, Preschool, Country of Research: Islamic Republic of Iran Type of Research: Clinical Keywords: Maternal, Reproductive and Child Health,Child Health, Constipation ,Cross-Sectional Studies ,Child ,Chronic Disease
Celiac disease is an autoimmune mediated small intestine inflammation which occurs due to hypersensitivity reaction to gluten and related proteins in diet in genetically predisposed individuals.
Prevalence of celiac among the population is about 0.5 - 1 % in most countries. Frequency of celiac disease in children is the subject of a few research. In this study, we aim to determine the frequency of celiac disease in patients presenting with functional constipation. This cross-sectional study was conducted on children referring to Imam Reza Clinic, affiliated to Shiraz University of Medical Sciences during one year starting from 2011, March 20. One hundred and one children 2-18 years of age with constipation for more than 2 months according to ROME III criteria. The entire participants underwent serologic studies of Total IgA and IgA TTG. Serum IgG TTG was measured in cases with reported values of Total IgA below the lowest normal limits. Moreover, endoscopic biopsy of the small intestine was also performed for patients with positive serology. Of all the 101 studied participants, only four individuals [3.96 %] had positive test results for IgA TTG [potential celiac disease] . One of these patients refused to do endoscopy and endoscopic small intestine biopsy was performed for 3 patients. Two of them had normal pathology and one of them [0.99 %] was confirmed for celiac disease. The frequency of celiac disease in children with chronic constipation is slightly higher than general population but without significant difference 0.99% VS 0.6% ; p=0.64] . So the screening serologic test for celiac disease is not recommended in children with chronic constipation
Seyed Mohsen Dehghani ,Zahra Ehsaei ,Naser Honar ,Hazhir Javaherizadeh ,
Frequency of celiac disease in children with chronic functional constipation in Shiraz-Iran,
Middle East J. Dig. Dis. 2015;
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