A topical o/w cream containing tretinoin microspheres was prepared. Gelatin microspheres of tretinoin were prepared using coacervation method. These microspheres contained about 50% w/w tretinoin.
The particle size range of microspheres was between 90-150 ىm. In vitro drug release from microspheres and a cream formulation was studied. It was shown that drug release from microspheres followed Higuchi kinetics of release. However, drug release from the cream formulation followed zero order release profile
Rasool Dinarvand ,Rasool Dinarvand ,Elham Rahmani ,Efat Farbod ,
Gelatin microspheres for the controlled release of all-trans-retinoic acid topical formulation and drug delivery evaluation,
Iran. J. Pharm. Res. 2003;
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