Shigella species are invasive enter bacteria that cause dysentery a sever form of diarrhea. The ability to invade epithelial cells is essential for virulence in a prototype Shigella species.
has shown here t that clinical isolates of Shigella dysenteries were investigated. GEB 937 lacked a small plasmid 4.3 kb [plasmid pSA1] , exhibited reduce invasiveness for Hep-2 cells, and failed to produce the somatic antigen. The transfer of this plasmid into Escherichia coil MM294 confirmed the conclusion that pSAl encodes one or more function involved in O-antigen [lipopolysaccharide] biosynthesis and bacterial virulence. A plasmid of similar size as detected in all of the other strain of Shigella species examined
Aseel R. Aboud ,Aseel R. Aboud ,Samira Y. Yosuf ,
Genetic and physical evidence for plasmid in Shigella species specifies one or more function essential for O-antigen,
J. Fac. Med. -Baghdad. 2004;
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