COVID-19 | Discover the latest peer-reviewed research articles from the Eastern Mediterranean Region
COVID-19 | Discover the latest peer-reviewed research articles from the Eastern Mediterranean Region
COVID-19 | Discover the latest publications published by WHO Regional Office for the Eastern Mediterranean
COVID-19 | Discover the latest publications published by WHO Regional Office for the Eastern Mediterranean

Virtual Health Sciences Library

  • Home
  • Search
  • Knowledge Base
  • Get a journal indexed in the Index Medicus
  • MyVHSL
  1. Home
  2. IMEMR
  3. Search Result
  4. Genotoxic and cytotoxic effects of sunset yellow and brilliant blue, colorant food additives, on human blood lymphocytes

Genotoxic and cytotoxic effects of sunset yellow and brilliant blue, colorant food additives, on human blood lymphocytes

Authors

Kus Esra
Eroglu, Halil Erhan
Bozok University ; , Science Institute ; , Department of Biology ;

Pak. J. Pharm. Sci. 2015; 28 (1): 227-230
Pakistan Journal of Pharmaceutical Sciences
Journal Country: Pakistan
P-ISSN: 1011-601X
Type of Publication: Journal Article
Category: Humans,
Type of Research: Clinical
Keywords: Food Additives / Toxicity
Board Subjects: Noncommunicable Diseases, Lymphocytes ,Azo Compounds ,Benzenesulfonates ,DNA Damage
Citation: Esra Kus ,Halil Erhan Eroglu , Genotoxic and cytotoxic effects of sunset yellow and brilliant blue, colorant food additives, on human blood lymphocytes, Pak. J. Pharm. Sci. 2015; 28 (1): 227-230

Abstract English

The synthetic dyes over fifty are used in many areas including the food industry around the world. Sunset Yellow FCF and Brilliant Blue FCF are used as colorant food additives in many food products. The present study investigated the genotoxic and cytotoxic effects of Sunset Yellow and Brilliant Blue. Genotoxic and cytotoxic activities of the food additives were evaluated in lymphocyte cell cultures using mitotic index, replication index and micronucleus assay. Mitotic index frequencies and replication index values were decreased and micronucleus frequency was increased with increasing concentrations of Sunset Yellow and Brilliant Blue. The changes in mitotic index and micronucleus are statistically significant [p<0.05] . The results show that the Sunset Yellow and Brilliant Blue can have cytotoxic and genotoxic potential. It care must be taken when using these materials as a food additive

Full Text English
1 Downloads

Subscribe to VHSL Newsletters

© 2020 WHO – EMRO