ambient signaling processes to ROS-mediated pathophysiological consequences. Oxidative stress has been implicated in the installation and progression of several degenerative diseases via DNA mutation, protein oxidation and lipid peroxidation. Therefore, possible use of soursop fruit extract to protect brain against the Lipid peroxidation Objective: The present study was undertaken to evaluate the potential of Soursop [Annona Muricata L.] against the DPPH Free Radical Scavenging System and Lipid peroxidation Methods: Phytochemical screening was carried out with fruit extract of A. muricata for the detection of various phytochemicals. The extract was tested for the presence of glycosides, proteins, saponins, tannins, phenolic compounds, alkaloids, flavonoids, steroids and vitamin C using the standard procedures and then DPPH radical was estimated according to the method of Blois and Lipid peroxidation was estimated according to the method of Rajakumar Conclusion: The results suggest that Soursop [Annona Muricata L.] treatment protects the rat brain against lipid peroxidation and DPPH free radical scavenging