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  4. Identification of some Annona Muricata L. [Soursop]components and their antioxidant effects in rats

Identification of some Annona Muricata L. [Soursop]components and their antioxidant effects in rats

Authors

Abbas Sarah Isam
Mohammed, Mustafa, Taha
Abdal Mandi, Rehab
Al-Mustansiriyah University ; , College of Science ; , Department of Chemistry ;

Pak. J. Med. Res. 2015; 14 (4): 576-580
IPMJ-Iraqi Postgraduate Medical Journal
Journal Country: Iraq
P-ISSN: 1608-8360
Type of Publication: Journal Article
Category: Animals, Laboratory,
Country of Research: Iraq WHO Eastern Mediterranean Region
Type of Research: Experimental Studies
Keywords: Annona
Broad Subjects: Health Systems, Antioxidants ,Free Radical Scavengers ,Oxidative Stress ,Lipid Peroxidation ,Plant Extracts ,Phytotherapy ,Plants, Medicinal
Citation: Sarah Isam Abbas ,Mustafa Taha Mohammed ,Rehab Abdal Mandi , Identification of some Annona Muricata L. [Soursop]components and their antioxidant effects in rats, Pak. J. Med. Res. 2015; 14 (4): 576-580

Abstract English

Background: Oxidative stress defines that, the level of Reactive Oxygen Species [ROS] exists in excess of antioxidant defenses. This imbalance in the redox milieu results in a switch from ROS-stimulated ambient signaling processes to ROS-mediated pathophysiological consequences. Oxidative stress has been implicated in the installation and progression of several degenerative diseases via DNA mutation, protein oxidation and lipid peroxidation. Therefore, possible use of soursop fruit extract to protect brain against the Lipid peroxidation Objective: The present study was undertaken to evaluate the potential of Soursop [Annona Muricata L.] against the DPPH Free Radical Scavenging System and Lipid peroxidation
Methods: Phytochemical screening was carried out with fruit extract of A. muricata for the detection of various phytochemicals. The extract was tested for the presence of glycosides, proteins, saponins, tannins, phenolic compounds, alkaloids, flavonoids, steroids and vitamin C using the standard procedures and then DPPH radical was estimated according to the method of Blois and Lipid peroxidation was estimated according to the method of Rajakumar Conclusion: The results suggest that Soursop [Annona Muricata L.] treatment protects the rat brain against lipid peroxidation and DPPH free radical scavenging

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