Insulin resistance and cognitive impairment in type II diabetes mellitus
Assiut Medical Journal Journal Country: Egypt
P-ISSN: 1110-0494 Type of Publication: Journal Article Category: Humans, Female, Male, Middle Aged, Aged, Type of Research: Clinical
Keywords: Diabetes Mellitus, Type 2
Broad Subjects: Noncommunicable Diseases, Insulin Resistance ,Cross-Sectional Studies ,Hemoglobin A, Glycosylated ,Cognition Disorders
Citation: Mostafa G. Mohamed , Insulin resistance and cognitive impairment in type II diabetes mellitus, Assiut Med. J. 2015; 39 (3): 195-208
Background: Type II Diabetes mellitus [DM] is a metabolic disorder that is characterized by high blood glucose because of the insulin resistance. Significant 1 more interest has been dedicated to the effect of type II diabetes on the brain. Along with cerebrovascular disease, type II diabetes is implicated in the development of other neurological co-morbidities Aim of the work: To study cognitive functions in type II DM and the effect of insulin resistance on it
Subjects and methods: In the present study, cognitive function tests were done for 37 subjects; control [n= 17] , type II DM [n= 20] . These tests include mini mental state examination [MMSE] , Wechsler adult intelligence scale [WAIS] , Wechsler memory scale [WMS] and Cognitive Event related potential [P300] . Circulating levels of glycosylated haemoglobin [HbA [1c] and insulin were determined in venous blood samples of both groups Conclusion: type II DM is associated with cognitive impairment which may be due to insulin resistance
