It has been shown that activated T-cells produce and release both IL-2 and IL 2 receptors [IL-2R] . The rate of IL-2 release is proportional to its cell surface expression and state of cell activation.
To clarify the molecular basis of this immunological aberration, we analysed the amount of soluble IL-2R[SIL2-R] by an ELISA technique in 68 patients with Behcet's disease [BD] , 28 patient controls [PC] and 31 normal controls [NC] . The data suggest that the amount of SIL-2R in BD is significantly higher [P<0.005] than that of NC. The same differences were seen between PC and NC[P<0.005] . However the level of SIL-2R in BD and PC were similar. This study suggests that inhibition of an immunoregulatory cytokine by its soluble receptors might occur in Vivo, as the reduction of SIL-2R levels approaching control values preceded clinical remission
M. Raiani ,A. Massoud ,F. Davatchi ,
Levels of soluble IL-2 receptors in sera of Iranian patients with Behcet’s disease,
Med. J. Islamic Rep. Iran. 1994;
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