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  4. Mean platelet volume, red cell distribution width and ischemia modified albumin as a marker of oxidative damage and inflammation in obese children

Mean platelet volume, red cell distribution width and ischemia modified albumin as a marker of oxidative damage and inflammation in obese children

Authors

Aylanc Hakan
Battal, Fatih
Yildirim, Sule
Kaymaz, Nazam
Tekin, Mustafa
Turkun, Hakan
Canakkale Onsekiz Mart University ; , Faculty of Medicine ; , Department of Pediatrics ;

Kuwait Med. J. 2015; 47 (4): 308-312
KMJ-Kuwait Medical Journal
Journal Country: Kuwait
P-ISSN: 0023-5776
Indexing Status : In process
Citation: Hakan Aylanc ,Fatih Battal ,Sule Yildirim ,Nazam Kaymaz ,Mustafa Tekin ,Hakan Turkun , Mean platelet volume, red cell distribution width and ischemia modified albumin as a marker of oxidative damage and inflammation in obese children, Kuwait Med. J. 2015; 47 (4): 308-312

Abstract English

Objectives: Childhood obesity is an important risk factor for adulthood obesity. The objective of this study was to evaluate the relationship between red cell distribution widths [RDW] , ischemia modified albumin [IMA] , mean platelet volume [MPV] and childhood obesity Design: Prospective case-control study. Setting: General pediatric outpatient clinics of the Department of Pediatrics, Canakkale Onsekiz Mart University Hospital, Turkey. Subjects: One hundred and seven [57 obese and 50 normal weight] children and adolescents [aged 5-18 years]
Interventions: Age, gender, body mass index [BMI] were recorded. The serum IMA and complete blood count level of the subjects were measured. RDW, MPV, hemoglobin [Hb] , hematocrit [Hct] , mean corpuscular volume [MCV] , red blood cell [RBC] , platelet count and white blood cell [WBC] count were measured as part of the automated complete blood count Main Outcome Measures: The RDW and IMA were found significantly higher in obese children and adolescents than normal weighted ones [p < 0.001] . MPV values were minimally increased in obese subjects as compared to normal weighted peers [p = 0.05] Results: Hb, MCV, platelet and WBC counts were similar between normal and obese subjects. The Hct and RBC count were significantly higher in obese subjects Conclusions: In the present study we demonstrated that IMA and RDW levels are significantly higher in obese children and adolescents as compared to those with normal weight. The IMA and RDW had positive correlation with BMI. These results support that oxidative and inflammatory processes of obesity begin in childhood

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