this can leads to compromise of the systemic blood flow. Recently Superior vena cava [SVC] flow is usecl to asses' systemic blood flow Aim of the work: The aim of this work was to study cardiac output changes using SVC flow in neonates with perinatal hypoxia Subjects and Methods: This observational prospective study was conducted between March 2015 and August 2 [] 15 at the Neonatal Intensive Care Unit [NICU] and the normal neonaral ward of Alexandria University Hospital [Al-Shatby] on 30 asphyxiated full term neonates [Group I] and 30 healthy full term neonates [Group Il] . Superior yena cava [SVC] flow was measured in the first 3 days of life by Doppler echocardiography using Kluckow and Evans method Conclusion: In conclusion, the assessment Superior vena cava [SVC] flow changes in the early neonatal period is likely to be of great importance in predicting rnyocardial dysfunction. Developing a functional echocardiography [fEHO] service will provide the important hemodynamic information which is critical in the management of asphyxiated infants