0bjective: Oxidative stress has been recently implicated in the pathogenesis of various diabetic complications, consequently the potential protective effects of antioxidant agents has been raised.
This study explores the potential protective effect of aspirin [Acetyl Salicylic Acid] on the oxidative stress induced by hyperglycemia of diabetes Methods: The study included twelve patients with type -l diabetes. twenty two patients with type-2 diabetes and twenty four apparently healthy non-diabetic subjects as control. All subjects were treated with 100 mg aspirin given orally once daily for a period of eight weeks
Results: Aspirin-treatment was able to lower significantly the susceptibility of diabetic tissues to increased oxidative stress. This effect was manifested by reduced malondialdehyde production by erythrocytes and plasma of these patients; in response to in vitro challenge with hydrogen peroxide [H  0  . A corresponding increase in the levels of the erythrocyte glutathione was also noticed after aspirin treatment Conclusion: These findings would confirm the suggested beneficial effect of Aspirin treatment in diabetes through reducing the risks of coronary head diseases. which could be related to the ability of aspirin to modulate the damage induced by the oxidative stress in diabetic patients
Shatha H. Ali ,Shatha H. Ali ,Ahmed M. Sultan ,
Modulation of damage induced by oxidative stress in diabetic patients by aspirin treatment,
Iraqi J. Community Med. 2003;
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