Background: Chronic Myeloid Leukemia [CML, ] , a clonal proliferative disorder of the multipotent stem cells, is frequently associated with myelofibrosis, which describes an increased deposition
of collagen in the bone marrow Patients and Methods: In 58 patients with nonblastic chronic myeloid leukemia the incidence and degree of marrow fibrosis were assessed in early stage of disease, the main features from the initial bone marrow biopsy were estimated together with clinical and haem3tologial parameters and analyzed for elucidation of the relationship between development of marrow fibrosis [MF] and various clinical and haematological features of CML.
Results: The significant myelofibrosis, [moderately-markedly increase] was demonstrated in 52% of the cases, and it was significantly correlated with splenomegally, hepatomegally, anemia, leucocytosis, thrombocytosis and increasing number of erythroblasts and blasts in peripheral blood count. Among the marrow features, the number of MKCs/sq. mm. , blood vessels, trabecular bone width, and the osteoblast index were significantly correlated with the degree of fibrosis Conclusion: Estimation of reticulin fibrosis is a useful biologic and prognostic index in newly diagnosed patients with chronic myeloid leukemia
%ad S. Mansoor ,%ad S. Mansoor ,Fatima A. Al Rawi ,Talal Al Samaraee ,
Myelofibrosis in chronic myeloid leukemia: a clinicopathologic study on 58 patients,
Iraqi J. Med. Sci. 2003;
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