This study was applied on 30 adult patients [21 males and 9 females] presented by chronic bronchial asthma and symptoms of GERD who were refractory to conservative anti-asthma medical lines.
assessment, X-ray chest, esophagography, pulmonary function tests before and after bronchodilators, tests to confirm GERD and upper GI endoscopic examination including lower esophageal multiple biopsies were done to all cases. Six out of 30 patients underwent Nissen fundoplication as a selected surgical anti-reflux technique. Esophagitis was detected in 96.6% of cases, endoscopic evidence of GERD was shown in 63.3%, anti-reflux treatment together with bronchodilators have caused clinical reversibility of airway obstruction by 20% or more as proved by pulmonary function parameters tested. Anti-reflux conservative treatment has achieved good response in 24 patients. Regarding the 6 patients who were subjected to surgery, 5 of them showed marked clinical and pulmonary functions improvement with decreased frequency of exacerbations, reduction of bronchodilator dose and disappearance of reflux symptoms. One patient failed to show clinical response
Mohamed M. El Shafie ,Samy M. Osman ,Aly M. Abdel Wahab ,
Nissen fundoplication for the treatment of chronic asthmatic patients,
Assiut Med. J. 1994;
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