Background: As a crucial constituent of tissue microenvironment, extracellular matrix [ECM] proteins can modulate tissue microenvironment and regulate the behavior of the surrounding cells.
Periostin is usually absent or expressed in low levels in most adult tissues; however, it is often highly expressed during inflammation, injury and in multiple tumors as recently reported. Alterations in glycosylation regulate the development and progression of cancer, serving as important biomarkers and providing a set of specific targets for therapeutic intervention Results: In current study, evidence showed that Periostin is overexpressed in ovarian cancer in a tumor type specific glycosylated form that affects Notch levels and activation. Moreover, ovarian cancer cell lines that constantly express glycosylated periostin showed enhanced Notch 1, 3 levels as well as Notch downstream effectors; Hes1, and NRARP. Our experiments in mice xenograft models showed increased carcinogenicity and metastatic potential in tumors produced by cells expressing glycosylated periostin forms
Conclusions: These results indicate that glycosylated periostin overexpression can in turn alter the carcinogenic potential of tumor cancer stem cells [CSC]
Heba Allam ,Heba Allam ,Karen Abbott ,
Periostin is needed for maintenance of ovarian cancer stem cells: role in carcinogenicity and metastasis,
Egypt. J. Med. Microbiol. 2017;
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