It is believed that immune complexes play a role in the development of renal pathology in preeclampsia. To ensure this, 10 cases with residual proteinuria were biopsied 2-4 weeks postpartum.
biopsies were studied by light microscopy and tested for immunofluorescence [IF] . Light microscopy revealed the occurrence of endotheliosis, together with axial mesangial cellular proliferation with or without increase of matrix and one specimen showed focal segmental sclerosis. In addition, tubular degeneration [7 cases] and interstitial lymphocytic infiltration [2 cases] were noticed. IF showed positive granular subendothelial and mesangial deposits of IgM [9 cases] , IgG [6 cases] , C3 [5 cases] and fibrin [7 cases] . Renal biopsies of 2 cases with postpartum hemorrhage leading to acute renal failure, revealed endotheliosis but showed no deposits by IF. The placentae of 8 of the cases and 8 normal primigravida labors were tested for deposits by IF and revealed the occurrence of fibrin deposits and negligible immunoglobulins in most of the specimens and C3 and C4 deposits in 4 of the preeclampsia cases. These findings suggested an important pathogenic role of immune complexes in renal involvement in preeclampsia
Mohammed G. Saadi ,
Post-partum renal light microscopy and detection of immune deposits in pre-eclampsia,
Med. J. Cairo Univ. 1994;
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