Diabetes mellitus is associated with development of macro- and microvascular complications. Although diabetes is a risk factor by itself, diabetes is often associated with a hypercoagulable state.
Increased platelet adhesion and aggregation have been reported in patients with diabetes mellitus. Platelet derived microparticles [PMP] produced by platelet activation or by physical stimulation under various conditions have coagulative activity. We measured and compared levels of PMP using flow cytometric analysis in diabetic patients with and without vascular complications: 20 with macrovascular complications [group III] , 20 with microvascular complications [group IV] , and 20 without vascular complications [group 11] ; and in normal control subjects [group I] , trying to find the possible relation, if any, between PMP levels and the presence and the degree of different vascular complications. There was a significant difference between the four groups. PMP levels was significantly higher in diabetic patients compared to controls. It was also significantly higher in diabetics with vascular complications compared to those without complications. Among those with complications it was significantly higher in those with macrovascular complications. Moreover, in diabetic patients, PMP level was positively and significantly correlated with carotid arteries intima-media thickness [CAA-IMT] , degree of proteinuria, score of peripheral neuropathy, and with the degree of retinopathy which suggest the possible role of PMP in the presence and severity of these complications
Ezzat Mustafa Mohamed ,Ezzat Mustafa Mohamed ,Hisham M. Omar ,Farida M. Elfawal ,
Potential role of platelet-derived microparticles in diabetic vascular complications,
J. Egypt. Soc. Nephrol. 2003;
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