In a comparative study, 40 children were included in 2 equal groups to study the characteristics of either propofol or thiopentone as a sole anaesthetic agent in minor day-stay surgical procedures.
Propofol was given in a dose of 2.5 mg. Kg[-1] , while thiopentone was given in a dose of 4-5 mg. Kg[-1] . It was found that respiratory rate, systolic, diatolic and mean arterial blood pressures decreased significantly from the preinduction values [P< 0.05] . The heart rate decreased significantly after propofol, while it showed a significant increase after thiopentone administration. The incidence of pain on injection was significantly more in propofol than in thiopentone injection. Airway obstruction was seen in 25% of propofol group, while it was manifested in 40% of thiopentone group. Mild laryngeal spasm was manifested in 5% of propofol group patients, while it was seen in 15% of thiopentone group patients. Apnoea occurred in 25% of propofol group children and in 10% of thiopentone group children. It was of longer duration in the former group. Propofol was associated with significantly rapid and clear recovery from anaesthia than thiopentone, otherwise it offers no advantage over thiopentone as a short-acting anaesthetic agent
A. A. Metwally ,M. A. El Erian ,Hamed Mohamed A. Osman ,
Propofol versus thiopentone as a sole anaesthetic agent in children: a comparative study,
Tanta Med. J. 1993;
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