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  4. Protective effect of broccoli and ferulic acid on imidacloprid-induced hepatotoxicity in rat

Protective effect of broccoli and ferulic acid on imidacloprid-induced hepatotoxicity in rat

Authors

Ahmed Mahgoub M.
Nasr, Sawsan A.
National Organization for Drug Control and Research [NODCAR] ; , Molecular Drug Evaluation Department ;

Egypt. J. Biochem. Mol. Biol. 2015; 33 (2-Jan): 1-15
EJB-The Egyptian Journal of Biochemistry and Molecular Biology
Journal Country: Egypt
P-ISSN: 1687-1502
Type of Publication: Journal Article
Category: Animals, Laboratory,
Country of Research: Egypt WHO Eastern Mediterranean Region
Keywords: Brassica
Broad Subjects: Health Systems, Imidazoles ,Nitro Compounds ,Coumaric Acids ,Plant Extracts ,Oxidative Stress ,Rats ,DNA Damage
Citation: Mahgoub M. Ahmed ,Sawsan A. Nasr , Protective effect of broccoli and ferulic acid on imidacloprid-induced hepatotoxicity in rat, Egypt. J. Biochem. Mol. Biol. 2015; 33 (2-Jan): 1-15

Abstract English

Imidacloprid may induce oxidative stress leading to generate free radicals and alternate oxygen free radical scavenging enzyme system. This study aims to investigate the hepatoprotective effect of broccoli water extract and ferulic acid on imidacloprid induced oxidative stress and DNA damage in male albino rats. Rats were co-treated with broccoli water extract [200 mg/kg] or ferulic acid [20 mg/kg] with imidacloprid [80 mg/kg] orally for 28 days. The results revealed that imidacloprid induced high serum levels of aspartate aminotransferase [AST] , alanine aminotransferase [ALT] and alkaline phosphatase [ALP] . However, administration of broccoli and ferulic acid reduced these parameters. Broccoli and ferulic acid significantly [Pbroccoli and ferulic acid treated groups. The possible mechanism of broccoli and ferulic acid extract on imidacloprid might be due to decreasing oxidative stress [LPO, NO and DNA damage] and increasing GSH content. Thus, broccoli and ferulic acid was suggested to protected rat’s liver against imidacloprid-induced oxidative stress and DNA damage in liver

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