COVID-19 | Discover the latest peer-reviewed research articles from the Eastern Mediterranean Region
COVID-19 | Discover the latest peer-reviewed research articles from the Eastern Mediterranean Region
COVID-19 | Discover the latest publications published by WHO Regional Office for the Eastern Mediterranean
COVID-19 | Discover the latest publications published by WHO Regional Office for the Eastern Mediterranean

Virtual Health Sciences Library

  • Home
  • Search
  • Knowledge Base
  • Get a journal indexed in the Index Medicus
  • MyVHSL
  1. Home
  2. IMEMR
  3. Search Result
  4. Rapid determination of indapamide in pharmaceuticals and human urineusing square-wave adsorptive stripping voltammetric technique

Rapid determination of indapamide in pharmaceuticals and human urineusing square-wave adsorptive stripping voltammetric technique

Authors

Ahmed Salwa A.
Abdel Gaber, Ahmed A.
Abdel Rahim, Asmaa M.
Minia University ; , Faculty of Science ; , Chemistry Department ;

Jordan Med. J. 2015; 8 (2): 105-118
Jordan Journal of Pharmaceutical Sciences
Journal Country: Jordan
P-ISSN: 1995-7157
Indexing Status : In Process
Citation: Salwa A. Ahmed ,Ahmed A. Abdel Gaber ,Asmaa M. Abdel Rahim , Rapid determination of indapamide in pharmaceuticals and human urineusing square-wave adsorptive stripping voltammetric technique, Jordan Med. J. 2015; 8 (2): 105-118

Abstract English

Square-wave adsorptive stripping voltammetric method was selected for the investigation of the adsorbed Indapamide [INDP] drug in solutions of varying pH. A method has been developed for the ultra trace determination of INDP inpresence Cu [II] , due to the strong adsorption of the Cu [II] – INDP complex at the surface of the HMDE andsubsequent reduction of the surface – bound complex. The observed data has been subjected to statistical analysis, which revealed high reliability and precision. A detection and quantitation limits of 2.9×10 [-11] and 8.8×10 [-11] mol/L [-1] respectively, were achieved in presence of 5.0×10 [-7] mol/L [-1] Cu [II] . The proposed procedure is much simple, fast, more sensitive, reproducible and the calibration graph is linear over range 2.0×10 [-12] -2.0×10 [-7] mol/L [-1] . Moreover, this method was successfully applied to the direct determination of INDP in pharmaceuticals and spikedhuman urine. No prior extraction step is needed in case of urine. The effect of some interferences [Mg [+2] , glycine, Fe [+3] , uric acid, starch, glucose and Na [2] CO [3] was considered

Full Text English
1 Downloads

Subscribe to VHSL Newsletters

© 2020 WHO – EMRO