Background and. Aim: Lichen planus [LP] is a chronic mucocutaneous disorder mediated by the impaired immunity' in which the concomitance of clinical and histopathological findings are necessary
for a definite diagnosis. In case of discrepancy between clinical and histopathological findings, use of adjunct diagnostic methods such as direct immunofluorescence [DIF] is recommended. This study sought to assess the repeatability of clinico histopathological findings and direct immunofluorescence of fixed, paraffin embedded specimens for diagnosis of LP. Matertuh and Methods: In this retrospective descriptive study, 49 oral and cutaneous LP specimens were subjected to DIF assessment using fibrinogen, c3 and IgM. The intensity of fluorescence staining was graded as 0, I or 2' Findings were compared in each group and between oral and cutaneous LP groups using statistical tests.
Results: Statistical unulyr", "rr"aled a correlation between C3 and IgM expression [Spearman's rho: 0'697, p=0'000] ' which was more prominent in cutaneous specimens [p: 0.000] . Additionally, a correlation was observed between fibrinogen and IgM expression in oral LP [Spearman's rho: 0.764, p: 0.02] .
A. R. Ghannadan ,M. Seyedmajidi ,S. Mehrabi ,O. Abdolabadi ,P. Aminishakib ,A Bijani ,
[Repeatabilifi of ctinico-histopathologiculft. ndings and direct immanoflaotescence offtxed, paraffin embedded specimens fot diugnosis of lichen planas],
J. Islam. Dent. Assoc. Iran. 2015;
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