Anti-LKM I typically occurs in the absence of SMA and ANA and is the serologic marker of type 2 AIM. The 50 KD antigen of LKM-1 autoantibodies was identified as cytochrome P450 2D6 [CYP 2D6].
The aim of the study is to know the prevalence and clinical relevance of anti-LKMl autoantibody in AIH Anti-liver kidney microsome type 1 [LKM-1] autoantibodies were studied by indirect immuno florescence assay [IIF] and confirmed by immunoblot in the serum of 73 Iraqi patients with autoimmune hepatitis [AIH] in comparison with 20 patients control [HBV infection] and 20 healthy individuals. Anti-LKMl autoantibodies were present in sera of sixteen patients [22%] with AIH and never in the sera of patients or healthy controls. It was concluded the anti-LKM 1 autoantibodies characterize patients with sever form of the autoimmune disease, poor prognosis and rapid progression to cirrhosis
Eman Sh. Al Obeidy ,Khalida M. Mousawy ,Maan G. Hasso ,Makki H. Fatadh ,Nawal M. Al Khalid ,
Roleof liver/kidney microsomal antibody type 1 with type 2- autoimmune hepatitis,
J. Fac. Med. -Baghdad. 2006;
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