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  4. Screening of different extracts from artemisia species for their potential antimalarial activity

Screening of different extracts from artemisia species for their potential antimalarial activity

Authors

Mojarrab Mahdi
Naderi, Rozhin
Afshar, Fariba Heshmati
Kermanshah University of Medical Sciences ; , Novel Drug Delivery Research Center ; School of Pharmacy,

Iran. J. Pharm. Res. 2015; 14 (2): 603-608
IJPR-Iranian Journal of Pharmaceutical Research
Journal Country: Islamic Republic of Iran
P-ISSN: 1735-0328
E-ISSN: 1726-6890
Type of Publication: Journal Article
Type of Research: Experimental Studies
Keywords: Artemisia
Broad Subjects: Health Systems, Plant Extracts ,Antimalarials
Citation: Mahdi Mojarrab ,Rozhin Naderi ,Fariba Heshmati Afshar , Screening of different extracts from artemisia species for their potential antimalarial activity, Iran. J. Pharm. Res. 2015; 14 (2): 603-608

Abstract English

The formation of hemozoin [malaria pigment] has been proposed as an ideal drug target for antimalarial screening programs. In this study, we used an improved, cost-effective and highthroughput spectrophotometric assay to screen plant extracts for finding novel antimalarial plant sources. Fifteen extracts with different polarity from three Iranian Artemisia species, A. ciniformis, A. biennis and A. turanica, were assessed for their antimalarial activity by invitro beta-hematin formation assay. The most potent effect was observed in dichloromethane [DCM] extract of A. ciniformis with IC [50] and IC [90] values of 0.92 +/- 0.01 and 1.29 +/- 0.02 mg/ mL, respectively. Ethyl acetate [EtOAC] extracts of A. biennis and A. turanica also showed significant antimalarial activities with IC [50] values of 1.11 +/- 0.02 and 1.35 +/- 0.08 mg/mL and IC [90] values of 1.22 +/- 0.04 and 2.81 +/- 0.21 mg/mL, respectively. Based on these results, it is possible to conclude that the components with strong antimalarial activity have been concentrated in the medium-polar extracts

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