Monocrotophos [MCP] is an organophosphorus insecticide has both systemic and contact actions and has been used against insects. Thirty six male Balb/c mice were used. These were divided into
group [A, B, Al, Bl, A2, B2,]. MCP was given orally daily by gavage 175 [th] of LD50 [0.28 mg/l00gm of body wt], vitamin E and vitamin C was given orally daily by gavage @ 100 mg /kg body wt., while MCP+ Vitamine E and MCP + Vitamine C was also given. The signs of MCP toxicity include shivering, salviation and lacrimation. Scanining electron microscopy [SEM] revealed that of erythrocytes in control were perfect discocytes [D]. MCP treatment resulted in drastic alteration in the topography of erythrocytes. Vitamin E and Vitamin C treated mice revealed normal erythrocyte like that in control. MCP+ Vitamin E and MCP + vitamin C treated mice revealed almost normal of topography of erythrocyte. Pesticide exposure could be prevented by CO- administration antioxidant Vitamin E or Vitamin C.
Khalid Hamdan Gathwan ,
SEM study on cytotoxic effect of monocrotophos [MCP]on blood of mice,
Iraqi Postgrad. Med. J. 2006;
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